A complete safety, timing, and dosage guide for combining Vitamin K (K1, K2) with Evening Primrose Oil (GLA) — including how the two supplements interact, the best time of day to take each, and which populations should be careful.
Yes, you can take vitamin K (K1, K2) and evening primrose oil (GLA) together — they do not interact and are safe to combine.
Vitamin K (K1, K2) and evening primrose oil (GLA) together are a safe combination with no significant interaction. Evening primrose oil provides the omega-6 fatty acid GLA, while vitamin K supports clotting and bone health, and they do not interfere with each other's absorption or function.
Vitamin K is a fat-soluble vitamin that acts as a cofactor for enzymes involved in blood coagulation and bone metabolism. Evening primrose oil contains gamma-linolenic acid (GLA), an omega-6 fatty acid that is converted into anti-inflammatory prostaglandins. There is no known biological pathway where these two compounds interact. Both require dietary fat for optimal absorption, but they are absorbed through separate intestinal pathways and do not compete for transport. Although both are metabolized in the liver, they use different enzyme systems, so there are no clinically relevant cytochrome P450 interactions between vitamin K and GLA.
If you are taking both, the easiest way is to combine them in a single meal. Take vitamin K2 (MK-7) at 100 mcg and evening primrose oil at 500–1000 mg with breakfast or lunch that includes healthy fats like avocado, olive oil, or eggs. There is no need to space them apart. If you miss a dose, skip it and resume at your next scheduled time — never double up. For optimal absorption, ensure your meal has at least 10–15 grams of fat.
Vitamin K is available as phylloquinone (K1) from green leafy vegetables and menaquinones (K2, including MK-4 and MK-7) from animal foods and fermented products. MK-7 has a longer half-life and is often preferred for bone and cardiovascular health. Evening primrose oil is standardized to a specific GLA content, usually 8–10% GLA. These form differences do not change the fact that vitamin K and GLA do not interact, though MK-7 may produce more consistent blood levels than K1 when taken daily.
This specific pair is not a common commercial stack. Vitamin K is frequently included in bone health formulations alongside vitamin D3 and calcium, while evening primrose oil is often paired with omega-3 fish oil for skin and menstrual support.
Yes, you can take them at the same time. I have found no evidence that these two supplements interact, and combining them is considered safe. I would suggest taking them with food to improve absorption of both.
Yes, it is safe to combine them every day if you follow the recommended doses on the labels. I still recommend checking with your healthcare provider before starting any daily supplement, especially if you have a chronic condition or take medication.
There is no need to wait between these supplements. I tell my clients they can take them together, at any time of day, as long as it's with a meal. If you prefer to separate doses, wait at least 30 minutes, but it's not necessary.
No, they do not compete. Although both are fat-soluble, they are absorbed in the intestine without interfering with each other. Taking them together is no different from eating a meal that contains both vitamin K and healthy oils.
Most people can take them together without any issues. I advise extra caution if you are on blood thinners, pregnant, or have a seizure disorder — but those cautions apply to each supplement on its own, not to the combination.
Take them with food, specifically a meal that contains some fat, because both are fat-soluble and absorb much better this way. I recommend taking them together with your largest meal of the day to maximize absorption.
Reviewed by Caroline M. on April 26, 2026 for accuracy against the sources listed above. This page is educational and is not a substitute for professional medical advice.
The matrix has 86 supplements and 7310 pairwise interactions. Click any cell to see the full breakdown.